Research


The Department of Medicine at Brown University employs world-renowned physician scientists across multiple subspecialties including cardiology, gastroenterology, infectious diseases, HIV, pulmonary, general internal medicine and many other disciplines.  This provides a unique opportunity for medical residents to be mentored by faculty, and participate in, clinical and/or basic research.

All internal medicine residents at Brown participate in scholarly work or research projects during their residency. Scholarly work may include quality improvement projects or other work related to an academic pursuit. Under direct supervision of the medical faculty, residents have access to all research laboratories both at the hospitals and on the campus of Brown University.

Dr. Philip A. Chan, Residency Research Director, oversees the operation of the program. Dr. Chan is an NIH-funded physician scientist who is a past graduate of our Brown medicine residency program. Dr. Chan works with residents to ensure adequate support and guidance throughout the 3-part research process: Training, Execution, and Dissemination.

Training

  • Throughout the PGY-1 Year, interns will begin their training in research and prepare to start their own research project.
  • Interns receive an introduction to the Residency Research Program upon arrival to Brown during orientation.
  • All interns receive human subjects training to participate in clinical research.
  • Each February, Interns attend the Annual PGY-1 Research Retreat, where they learn about developing a research question, mentoring options, statistical methods and support and presentation/dissemination techniques.
  • Faculty research mentors are assigned based upon subspecialty interests.

Execution

  • Residents may take elective months in the PGY-2 and PGY-3 year dedicated to research projects.
  • Departmental resources exist to support research including biostatistics, IRB submissions, and other administrative and methodological issues.
  • Throughout the Academic Year, each Subspecialty Division within the Department of Medicine produces a noon conference research overview of the work being performed in that discipline. Part of the conference is conducted by a resident currently engaged in research with faculty mentors in the specific area.

Dissemination

  • Senior Resident Research Day is held each May as a forum for senior residents to present their posters. Four residents are selected for Podium presentations. Prizes and recognition are awarded for those efforts judged superior by a panel of faculty.
  • Residents may elect to submit abstracts to the Annual ACP Associates Competition either at the State or National Levels or both. Residents may also submit to other national or local conferences.
  • Residents are encouraged to write up their research for peer review publication in a major academic journal.

Recent Resident Awards for Research

  • Nadia Shaikh, MD, MS – ACP National Clinical Vignette Awardee 2016
  • Justin Van Klein, MD – ACP National Research Poster Awardee 2016

Past Projects & Publications

Research projects undertaken by medical residents have included original novel clinical and basic science investigations, clinical case reports, reviews of the literature, and other scholarly projects. Residents are encouraged to present their work at local and national meetings and to submit all projects for publication. Each year the Rhode Island Chapter of the American College of Physicians (ACP) and the Brown Department of Medicine co-sponsor the Annual ACP/Brown University Residents Research Day which boasts over 100 posters or presentations by Brown residents. Below are listings of selected projects and publications.


  • Selected Resident Publications

    Belok S, Parikh L, Robertson J. A Case of Stroke due to Pulmonary Venous Thrombosis. R. I. Med. J. (2013) 2016;99(2):40–1.


    Crawford AL, Aspry KE. Teaching Doctors-in-Training About Nutrition: Where Are We Going in 2016? R. I. Med. J. (2013) 2016;99(3):23–5.

    Godfrey MS, Jankowich MD. The Vital Capacity Is Vital: Epidemiology and Clinical Significance of the Restrictive Spirometry Pattern. Chest 2016;149(1):238–51.

    Grigoras CA, Zervou FN, Zacharioudakis IM, Siettos CI, Mylonakis E. Isolation of C. difficile Carriers Alone and as Part of a Bundle Approach for the Prevention of Clostridium difficile Infection (CDI): A Mathematical Model Based on Clinical Study Data. PLoS One 2016;11(6):e0156577.

    Guo C, Settipane RA. Clinical presentation, pathophysiology, diagnosis, and treatment of acquired and hereditary angioedema: Exploring state-of-the-art therapies in RI. R. I. Med. J. (2013) 2016;99(6):41–4.

    Hutchinson N, Baird GL, Garg M. Examining the Reading Level of Internet Medical Information for Common Internal Medicine Diagnoses. Am. J. Med. 2016;129(6):637–9.

    Karanika S, Paudel S, Zervou FN, Grigoras C, Zacharioudakis IM, Mylonakis E. Prevalence and Clinical Outcomes of Clostridium difficile Infection in the Intensive Care Unit: A Systematic Review and Meta-Analysis. Open forum Infect. Dis. 2016;3(1):ofv186.

    Maciag M, Sediva I, Alexander-Scott N. Submandibular Swelling and Fever Following Frenulectomy in a 13-Day-Old Infant. Clin. Pediatr. (Phila). 2016;

    Ripp K, Orellana V, Dugdale C, Punsoni M, Doberstein CE, Beckwith CG. The Masquerading Cyst: Extraparenchymal Neurocysticercosis Presenting as Acute Meningitis. Am. J. Med. 2016;129(3):e1–3.

    Shaw DJ, Maciag M, Bercovitch L. “I didn’t sign on to die”: The dermatologist’s ethical obligations during a deadly epidemic. J. Am. Acad. Dermatol. 2016;74(1):183–5.

    Steinberg MB, Akincigil A, Kim EJ, Shallis R, Delnevo CD. Tobacco Smoking as a Risk Factor for Increased Antibiotic Prescription. Am. J. Prev. Med. 2016;50(6):692–8.

    Wu CMY, Noska A. Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. BMJ Case Rep. 2016;2016.

    Calzón Fernández S, Fernández Ajuria A, Martín JJ, Murphy MJ. The impact of the economic crisis on unmet dental care needs in Spain. J. Epidemiol. Community Health 2015;69(9):880–5.

    Glavis-Bloom J, Vasher S, Marmor M, et al. Candida and cardiovascular implantable electronic devices: a case of lead and native aortic valve endocarditis and literature review. Mycoses 2015;58(11):637–41.

    Godfrey MS, Finn A, Zainah H, Dapaah-Afriyie K. Metronidazole-induced encephalopathy after prolonged metronidazole course for treatment of C. difficile colitis. BMJ Case Rep. 2015;2015.

    Guo C, Sato R, Rothman I. Painful skin lesions on the hands following black henna application. Cutis 2015;96(3):E5–6.

    Jackson M, Olefson S, Machan JT, Kelly CR. A High Rate of Alternative Diagnoses in Patients Referred for Presumed Clostridium difficile Infection. J. Clin. Gastroenterol. 2015;

    Janosky M, Bian J, Dhage S, et al. Primary large cell neuroendocrine carcinoma of the breast, a case report with an unusual clinical course. Breast J. 2015;21(3):303–7.

    Karanika S, Zervou FN, Zacharioudakis IM, Paudel S, Mylonakis E. Risk factors for meticillin-resistant Staphylococcus aureus colonization in dialysis patients: a meta-analysis. J. Hosp. Infect. 2015;91(3):257–63.

    Lee M-M, Salahuddin A, Garcia MJ, Spevack DM. Left ventricular early inflow-outflow index: a novel echocardiographic indicator of mitral regurgitation severity. J. Am. Heart Assoc. 2015;4(6):e000781.

    Lee RT, Ferreira J, Friedman K, Moss SF. A rare cause of constipation: obstructing small cell neuroendocrine carcinoma of the anal canal. Int. J. Colorectal Dis. 2015;30(9):1291–2.

    Maleszewski JJ, Orellana VM, Hodge DO, Kuhl U, Schultheiss H-P, Cooper LT. Long-term risk of recurrence, morbidity and mortality in giant cell myocarditis. Am. J. Cardiol. 2015;115(12):1733–8.

    Martin JM, Winer ES. Genomics in acute myeloid leukemia: from identification to personalization. R. I. Med. J. (2013) 2015;98(11):27–30.

    Nunez ER, Schenker Y, Joel ID, et al. Acutely Bereaved Surrogates’ Stories About the Decision to Limit Life Support in the ICU. Crit. Care Med. 2015;43(11):2387–93.

    Olefson S, Jackson M, Grand DJ, Charpentier KP, Makwana N, Promrat K. Identification of Nonalcoholic Fatty Liver Disease following Pancreatic Surgery in a Western Cohort Using a Novel Radiographic Technique. J. Clin. Transl. Hepatol. 2015;3(4):246–53.

    Olefson S, Moss SF. Obesity and related risk factors in gastric cardia adenocarcinoma. Gastric Cancer 2015;18(1):23–32.

    Christopher A. Paynter, Benjamin J. Van Treeck, Inge Verdenius, Agnes W.Y. Lau, Twinkle Dhawan, Kayla A. Lash, Elizabeth A. Bergamini, Chiazotam N. Ekekezie, Amna M. Hilal, Kristen N. James, Sadie Alongi, Sean M. Harper, Aaron J. Bonham, Kathy B. Baumgartner, Richard N. Baumgartner, Diane M. Harper. Adherence to cervical cancer screening varies by human papillomavirus vaccination status in a high-risk population. Prev. Med. reports 2015;2:711–6.

    Vaidya DC, Lakhani A, Telang GH. Leukemia cutis presenting as scrotal ulcerations in a patient with acute myelogenous leukemia. Cutis 2015;95(6):E18–20.

    Wang J, Stewart E, Dapaah-Afriyie K, Finn A. Mild encephalopathy with reversible splenial lesion in a patient with influenza A infection--first report in an adult patient in the USA. BMJ Case Rep. 2015;2015.

    Zervou FN, Zacharioudakis IM, Pliakos EE, Grigoras CA, Ziakas PD, Mylonakis E. Adaptation of Cost Analysis Studies in Practice Guidelines. Medicine (Baltimore). 2015;94(52):e2365.

    Murphy M, Fernápndez A, Daponte A. The Spanish public health workforce. Perspect. Public Health 2014;134(5):257–8.

    Rafelson W, Brown T. A piece of my mind. The half-wall. JAMA 2014;312(23):2501–2.

    Geng LN, Conway D, Barnhart S, Nowatzky J. Behcet’s disease with major vascular involvement. BMJ Case Rep. 2013;2013.

    Rafelson W. A piece of my mind. The warmth. JAMA 2013;310(15):1565–6.

  • Research Presented at National & Regional Conferences

    “Utilization of a Scoring Tool to Predict Patient Suitability to Undergo Low Dose Stress-First Myocardial Perfusion Imaging.”
    Michael Brunt, Arrighi, JA.
    Abstract &  Poster presented at 20th Annual Scientific Session of the American Society of Nuclear Cardiology; Washington, DC, September 17-20, 2015;


    Subacute Bacterial Endocarditis with Abiotrophia Defectiva,
    Delaney Conway , Beth Gentilesco
    Poster presented at 2016 Society of Hospital Medicine National Meeting, San Diego, CA

    “Laxative-induced Magnesium Toxicity”
    Christopher Lee; Bethany Gentilesco
    Poster presented at Society of Hospital Medicine National Meeting April 2015

    “Pulmonary rehabilitation for patients with pulmonary hypertension: a single center experience”.
    Csikesz N, Ming-Ming Lee, Krishnan I, Palmisciano A, Whittenhall M, Klinger J, Pierce J, Nici L, Ventetuolo CE.
    Poster presented at: American Thoracic Society. Annual Meeting; May 13-18; San Francisco, CA.

    “Multifocal Candida glabrata Pacemaker and Native Valve Endocarditis Treated with Echinocandins.”
    Poster presented at 2015 Society of General Internal Medicine meeting, Boston, MA.
    Meghan. Marmor

    “ACE-Inhibitor Associated Angioedema Incited by Minor Trauma.”
    S. Reddy MS4, Meghan. Marmor
    Poster presented at 2015 Society of General Internal Medicine, Boston, MA.

    “The Obstetric Trauma Patient: A Review of the Trauma Registry for a Tertiary Care Hospital.”
    Meghan Marmor, Banerjee, D. et al.
    Poster presented at 2015 North American Society of Obstetric Medicine. Banff, Canada.

    “Novel hereditary breast cancer gene mutations: Should there be greater concern regarding ovarian cancer risk?”
    Nicholas Nassikas, Wilbur JS S, Laprise JK K and Legare RD D
    Poster Presented at 2015 San Antonio Breast Symposium

    “Clostridium Difficile: The Spectrum of Diagnoses in Patients Referred for Fecal Microbiota Transplant.”
    Sidney Olefson
    Poster Presented at Digestive Disease Week. Washington, DC. May, 2015
    “Navigating a Tight Spot: Anastamotic Stenosis in Crohn’s Disease During Pregnancy.”
    Eric J. Mao , Sidney Olefson, Melissa Jackson , Samir A. Shah, MD
    Poster presented American College of Gastroenterology National Meeting, Honolulu, HI, October 2015

    “A Challenging Case of Diarrhea After Fecal Microbiota Transplant”.
    Colleen R. Kelly, MD , Sidney Olefson, Melissa Jackson
    Poster presented at American College of Gastroenterology National Meeting, Honolulu, HI, October 2015

    “A Fatal and Preventable Complication of Celiac Disease: A Call to Action”
    Malorie Simons , Madhu Ouseph , Diana Treaba , Shamlal Mangray , Steven Moss ;
    Poster presented at American College of Gastroenterology National Meeting, Honolulu, HI , October 2015

    “Continuous renal replacement therapy (CRRT) in patients with active cancer? Yes or no.”
    Karanovic D, Christopher Thomas, Read CA.
    CHEST Annual Meeting, Oct. 28, 2015; Montreal, QC.