Research


The Department of Medicine at Brown University employs world-renowned physician scientists across multiple subspecialties including cardiology, gastroenterology, infectious diseases, HIV, pulmonary, general internal medicine and many other disciplines.  This provides a unique opportunity for medical residents to be mentored by faculty, and participate in, clinical and/or basic research.

All internal medicine residents at Brown participate in scholarly work or research projects during their residency. Scholarly work may include quality improvement projects or other work related to an academic pursuit. Under direct supervision of the medical faculty, residents have access to all research laboratories both at the hospitals and on the campus of Brown University.

Dr. Philip A. Chan, Residency Research Director, oversees the operation of the program. Dr. Chan is an NIH-funded physician scientist who is a past graduate of our Brown medicine residency program. Dr. Chan works with residents to ensure adequate support and guidance throughout the 3-part research process: Training, Execution, and Dissemination.

Training

  • Throughout the PGY-1 Year, interns will begin their training in research and prepare to start their own research project.
  • Interns receive an introduction to the Residency Research Program upon arrival to Brown during orientation.
  • All interns receive human subjects training to participate in clinical research.
  • Each February, Interns attend the Annual PGY-1 Research Retreat, where they learn about developing a research question, mentoring options, statistical methods and support and presentation/dissemination techniques.
  • Faculty research mentors are assigned based upon subspecialty interests.

 

Execution

  • Residents may take elective months in the PGY-2 and PGY-3 year dedicated to research projects.
  • Departmental resources exist to support research including biostatistics, IRB submissions, and other administrative and methodological issues.
  • Throughout the Academic Year, each Subspecialty Division within the Department of Medicine produces a noon conference research overview of the work being performed in that discipline. Part of the conference is conducted by a resident currently engaged in research with faculty mentors in the specific area.

 

Dissemination

  • Senior Resident Research Day is held each May as a forum for senior residents to present their posters. Four residents are selected for Podium presentations. Prizes and recognition are awarded for those efforts judged superior by a panel of faculty.
  • Residents may elect to submit abstracts to the Annual ACP Associates Competition either at the State or National Levels or both. Residents may also submit to other national or local conferences.
  • Residents are encouraged to write up their research for peer review publication in a major academic journal.

 

Recent Resident Awards for Research

  • Fabio Lima, MD, MPH – “Best of the Best Abstract Award” at the 2017 Society for Cardiovascular and Angiography Intervention (SCAI) conference
  • Lolita Nidadavolu, MD – ACP National Clinical Vignette, First Place Awardee 2017
  • Zoe Weiss, MD, Meghan Nahass, MD & Alisha Goodrum, MD – ACP Clinical Vignette Finalists 2017
  • Jose Ruiz, MD – ACP Ressearch Finalist 2017
  • Nadia Shaikh, MD, MS – ACP National Clinical Vignette Awardee 2016
  • Justin Van Klein, MD – ACP National Research Poster Awardee 2016

 

Past Projects & Publications

Research projects undertaken by medical residents have included original novel clinical and basic science investigations, clinical case reports, reviews of the literature, and other scholarly projects. Residents are encouraged to present their work at local and national meetings and to submit all projects for publication. Each year the Rhode Island Chapter of the American College of Physicians (ACP) and the Brown Department of Medicine co-sponsor the Annual ACP/Brown University Residents Research Day which boasts over 100 posters or presentations by Brown residents. Below are listings of selected projects and publications.


  • Selected Resident Publications

    Farahnik B, Sharma D, Alban J, Sivamani RK.  Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review. Am J Clin Dermatol. 2017 Aug

    Raghunathan V, Louis D, Wirk B. Gastrointestinal Tract Amyloidosis Presenting With Pneumatosis Intestinalis. J Clin Med Res. 2017 Jul

    Le A, Farmakiotis D, Tarrand JJ, Kontoyiannis DP. Initial Treatment of Cancer Patients with Fluconazole-Susceptible Dose-Dependent Candidaglabrata Fungemia: Better Outcome with an Echinocandin or Polyene Compared to an Azole? Antimicrob Agents Chemother. 2017 Jul 25

    Koko KR, McCauley BM, Gaughan JP, Nolan RS, Fromer MW, Hagaman ALR, Choron RL, Brown SA, Hazelton JP. Kaolin-based hemostatic dressing improves hemorrhage control from a penetrating inferior vena cava injury in coagulopathic swine. J Trauma Acute Care Surg. 2017 Jul

    Vakharia JD, Goldsweig B, Rogg JM, Topor LS. Extrapontine Myelinolysis in a Child with Salt Intoxication. J Pediatr. 2017 Jul

    Sharma E, Arunachalam K, Di M, Chu A, Maan A. PVCs, PVC-Induced Cardiomyopathy, and the Role of Catheter Ablation. Crit Pathw Cardiol. 2017 Jun

    Simons M, Bautista J, Occhiogrosso R, Scott-Sheldon LA, Gohh R.  Acute hypocalcemia following kidney transplantation may depend on the type of remote parathyroidectomy: a retrospective cohort study. Clin Nephrol. 2017 Jun

    Patel R, Wattamwar K, Kanduri J, Nahass M, Yoon J, Oh J, Shukla P, Lacy CR.

    Health Care Student Knowledge and Willingness to Work in Infectious Disease Outbreaks.

    Disaster Med Public Health Prep. 2017 Jun 19

    Raghunathan V, Pelcovits A, Gutman D, Carino G. Cardiogenic shock from coronary vasculitis in granulomatosis with polyangiitis. BMJ Case Rep. 2017 Jun 29

    McCauley BD, Chu AF. Minimally Invasive Closure of the Left Atrial Appendage: A Non-Pharmacologic Approach to Prevention of Stroke in Patients with Atrial Fibrillation. R I Med J. 2017 May 1

    Lima FV, Yang J, Xu J, Stergiopoulos K. National Trends and In-Hospital Outcomes in Pregnant Women With Heart Disease in the United States. Am J Cardiol. 2017 May 15

    Lima FV, Gruberg L. Here we go Again: Trying to prevent contrast induced nephropathy. Cardiovasc Revasc Med. 2017 May 31

    Hardison SA, Pyon G, Le A, Wan W, Coelho DH. The Effects of Double Gloving on Microsurgical Skills. Otolaryngol Head Neck Surg. 2017 Apr 1

    Reidy J, Halvorson J, Makowski S, Katz D, Weinstein B, McCluskey C, Doering A, DeCarli K, Tjia J. Health System Advance Care Planning Culture Change for High-Risk Patients: The Promise and Challenges of Engaging Providers, Patients, and Families in Systematic Advance Care Planning. J Palliat Med. 2017 Apr

    Bailey G, Healy A, Young BD, Sharma E, Meadows J, Chun HJ, Wu WC, Choudhary G, Morrison AR. Relative predictive value of lung cancer screening CT versus myocardial perfusion attenuation correction CT in the evaluation of coronary calcium. PLoS One. 2017 Apr 24

    Yeh T, Soto AG, Quintos JB, Topor LS. Turner syndrome and pituitary adenomas: a case report and review of literature.J Pediatr Endocrinol Metab. 2017 Feb 1

    Chow EJ, Mermel LA. Hospital-Acquired Respiratory Viral Infections: Incidence, Morbidity, and Mortality in Pediatric and Adult Patients. Open Forum Infect Dis. 2017 Feb 3

    Zervou FN, Zacharioudakis IM, Kurpewski J, Mylonakis E.T2 Magnetic Resonance for Fungal Diagnosis. Methods Mol Biol. 2017

    Andreatos N, Zacharioudakis IM, Zervou FN, Muhammed M, Mylonakis E. Discrepancy between financial disclosures of authors of clinical practice guidelines and reportsby industry. Medicine (Baltimore). 2017 Jan

    Raghunathan VM, Sheng I, Lim SH. Intestinal dysbiosis and allogeneic hematopoietic progenitor cell transplantation. J Transl Med. 2016 Dec 3

    Siddique O, Rasla S, Clark S, Kokkirala A. A Case of Ileus and ST Segment Elevation. R I Med J. 2016 Nov 1

    Wuerth BA, Bonnewell JP, Wiemken TL, Arnold FW. Trends in Pneumonia Mortality Rates and Hospitalizations by Organism, United States, 2002-2011(1). Emerg Infect Dis. 2016 Sep

    Barnato AE, Schenker Y, Tiver G, Dew MA, Arnold RM, Nunez ER, Reynolds CF 3rd. Storytelling in the Early Bereavement Period to Reduce Emotional Distress Among Surrogates Involved in a Decision to Limit Life Support in the ICU: A Pilot Feasibility Trial. Crit Care Med. 2016 Sep 9.

    Shafto KV, Breen J, Decker D. Reimagining nutrition education in a teaching kitchen. Minn Med. 2016 Sept-Oct

    Cilia L, Parikh L, Ouseph MM, Stopa E, Atalay MK. Systemic Amyloidosis Masquerading as Intractable Cardiomyopathy. R I Med J. 2016 Oct 4

    Kanagavelu S, Flores C, Hagiwara S, Ruiz J, Hyun J, Cho EE, Sun F, Romero L, Shih DQ, Fukata M.

    TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF) Regulates CXCR5+ T helper Cells in the Intestine. J Clin Cell Immunol. 2016 Oct

    Kolte D, Spence N, Puthawala M, Hyder O, Tuohy CP, Davidson CB, Sheldon MW, Laskey WK, Abbott JD. Association of radial versus femoral access with contrast-induced acute kidney injury in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Cardiovasc Revasc Med. 2016 Jul 21

    Javan R, Bansal M, Tangestanipoor A. A Prototype Hybrid Gypsum-Based 3-Dimensional Printed Training Model for Computed Tomography-Guided Spinal Pain Management. J Comput Assist Tomogr. 2016 Jul-Aug

    Grigoras CA, Zervou FN, Zacharioudakis IM, Siettos CI, Mylonakis E. Isolation of C. difficile Carriers Alone and as Part of a Bundle Approach for the Prevention of Clostridium difficile Infection (CDI): A Mathematical Model Based on Clinical Study Data. PLoS One. 2016 Jun 3;

    Hutchinson N, Baird GL, Garg M. Examining the Reading Level of Internet Medical Information for Common Internal Medicine Diagnoses. Am J Med. 2016 Jun

    Guo C, Settipane RA. Clinical presentation, pathophysiology, diagnosis, and treatment of acquired and hereditary angioedema: Exploring state-of-the-art therapies in RI. R I Med J. 2016 Jun 1

    Winkler J, Chaudhry SP, Stockwell PH. Gemella Endocarditis Presenting as an ST-Segment-Elevation Myocardial Infarction Tex Heart Inst J. 2016 Jun 1

    Simons M, Ferreira J, Meunier R, Moss S. Primary versus Metastatic Gastrointestinal Melanoma: A Rare Case and Review of Current Literature. Case Rep Gastrointest Med. 2016

    Steinberg MB, Akincigil A, Kim EJ, Shallis R, Delnevo CD. Tobacco Smoking as a Risk Factor for Increased Antibiotic Prescription. Am J Prev Med. 2016 Jun

    Ripp K, Orellana V, Dugdale CPunsoni M, Doberstein CE, Beckwith CG. The Masquerading Cyst: Extraparenchymal Neurocysticercosis Presenting as Acute Meningitis. Am J Med. 2016 Mar

    Wang HY, Xu JJ, Zou HC, Reilly KH, Zhang CM, Yun K, Li YZ, Jiang YJ, Geng WQ, Shang H, Wang N. Sexual Risk Behaviors and HIV Infection among Men Who Have Sex with Men and Women in China:Evidence from a Systematic Review and Meta-Analysis. Biomed Res Int. Dec 2015

    Glavis-Bloom J, Vasher S, Marmor M, Fine AB, Chan PA, Tashima KT, Lonks JR, Kojic EM. Candida and cardiovascular implantable electronic devices: a case of lead and native aortic valve endocarditis and literature review. Mycoses. 2015 Nov

    Nunez ER, Schenker Y, Joel ID, Reynolds CF 3rd, Dew MA, Arnold RM, Barnato AE. Acutely Bereaved Surrogates' Stories About the Decision to Limit Life Support in the ICU. Crit Care Med. 2015 Nov

    Lee RT, Ferreira J, Friedman K, Moss SF. A rare cause of constipation: obstructing small cell neuroendocrine carcinoma of the anal canal. Int J Colorectal Dis. 2015 Sep

    Wang J, Stewart E, Dapaah-Afriyie K, Finn A. Mild encephalopathy with reversible splenial lesion in a patient with influenza A infection--first report in an adult patient in the USA. BMJ Case Rep2015 Jun 2

  • Research Presented at National & Regional Conferences

     “Efficacy and Safety of Biologic Therapy in Elderly Rheumatoid Arthritis Patients Compared to Young – A Systematic Review” , Dalal, D., Duran, J., Brar, T., Alqadi, D., Hallady, C., Lakhani, A., Rudolph, J.  Poster presented at EULAR, June 2017, Madrid, Spain

    “Opportunistic Screening For Bone Disease Using Abdominal Ct Scans Obtained For Other Reasons In Newly Diagnosed IBD Patients”, Dionne Rebello. Poster presented at Digestive Diseases Week, May 2017, Chicago, IL

    “Celiac Disease And Increased Risk Of Pneumococcal Infection: A Systematic Review And Meta-Analysis” , Malorie Simons. Poster presented at Digestive Diseases Week, May 2017, Chicago, IL

    “Outcomes of Endovascular versus Surgical Revascularization for Chronic Mesenteric Ischemia: Insights from the National Inpatient Sample Database,” Fabio V. Lima; Poster presented at Society for Cardiovascular Aniography and Innovations (SCAI) National Meeting, May 2017, New Orleans, LA

    “Impact of a quality initiative on warfarin time in therapeutic range in an outpatient geriatric practice” , Lolita Nidadavolu. Poster presented at American Geriatrics Society Annual Meeting, May 2017, San Antonio, TX

    “Association Between Maximal ACT and Bleedin Complication During Transradial vs. Transfemoral PCI” , David Louis.  Poster presented at Society for Cardiovascular Aniography and Innovations (SCAI) National Meeting, May 2017, New Orleans, LA

    “Rapid Development of Pulmonary Hypertension and Right Ventricular Failure Due to Large Vessel Intravascular Talcosis in an Intravenous Drug User”  Jeffrey Cumplido.  Poster presented at American Thoracic Society National Conference, May 2017, Washington, DC

    “Differences in Family Involvement in the Care of Patients in the Intensive Care Unit Based on Self-Identified Race/Ethnicity” , Eduardo Nunez.  Poster presented at American Thoracic Society National Conference, May 2017, Washington, DC

    “Predictors Of Long-Term RV Pacing In Patients Post Transcatheter Aortic Valve Replacement”, Esseim Sharma.  Oral presentation at European Cardiac Arrhythmia Society Annual Congress, April 2017, Rome, Italy

    “A permanently retained guidewire and subsequent management with anticoagulation, 12 years later”, Meghan Nahass, Alisha Goodrum, Thomas Bledsoe.  Poster presented at American College of Physicians Internal Medicine Meeting, March 2017, San Diego, CA

    “Recurrent Ascites Secondary to Extrinsic Inferior Vena Cava Compression in Polycystic Kidney Disease” , Lolita Nidadavolu.   Poster presented at American College of Physicians Internal Medicine Meeting, March 2017, San Diego, CA

    “TRIF regulates pathogenic Th17 cell generation that may cause severe inflammation in inflammatory bowel disease (IBD)” , Jose Ruiz. Poster presented at American College of Physicians Internal Medicine Meeting, March 2017, San Diego, CA

    Snap, Crackle, Pop: Pneumomediastinum In Two Heavy Marijuana Users” , Zoe Weiss.  Poster presented at American College of Physicians Internal Medicine Meeting, March 2017, San Diego, CA

    “Two Varicella Outbreaks at Different Prison Facilities in Rhode Island: Epidemiology and Response” , Matthew Murphy. Oral presentation at Academic & Health Policy Conference on Correctional Health, March 2017, Atlanta, GA

    “Using Mobile Device Technology and Spaced Education Adaptive Learning Algorithms to Teach ECG Interpretation”,  Brian D. McCauley.  Oral presentation at American College of Cardiology Scientific Sessions, March 2017 Washington, DC

    The Internist And The Uterus: How Are General Internists Failing Reproductive Age Women?”, Meghan Geary. Oral presentation at the SGIM New England Regional Metting, March 2017, Boston, MA

    “Hypotension and Vasopressor Use During Elective Surgery in Patients Advised to Continue Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Medications on the Day of Surgery” Katherine Scovner, Nicole Benson, Emily Stebbins, and Alex Fine.  Poster presented at Kidney Week 2016 Annual Meeting, November 2016 in Chicago, IL

    “Prostacyclin Therapy Suppresses Plasma BNP Levels Independent of Pulmonary Hemodynamic Effects

    in Patients With PAH” , Samuel Belok.  Poster presented at CHEST Annual Meeting, October 2016, Los Angeles, CA

    “An Unusual Etiology of Gastric Outlet Obstruction” Dionne Rebello, Eric Mao, Harlan Rich. Poster presented at American College of Gastroenterology National Meeting, Las Vegas, NV, October 2016

    “Initial treatment of cancer patients with fluconazole-intermediate C. glabrata fungemia with an echinocandin or polyene is associated with better survival than initial treatment with an azole” Audrey Le, Dimitrios Farmakiotis,  Jeffrey Tarrand and Dimitrios Kontoyiannis. Poster presented at ID Week 2016, October 2016, New Orleans, LA

    “TEACH: A New Model to Engage Local Students in Community Health” Eric Chow, Jackie Hsieh, , Margret Chang. Poster presented at American Academy of Pediatrics National Conference, October 2016, San Francisco, CA

    "Teaching Motivational Interviewing to Residents in a Small Group Setting", Alisha Goodrum. Poster presented at Society of General Internal Medicine New England Regional Meeting, New Haven , CT. March 2016

    “Ethical Conundrums in Refugee Health” Meghan Geary  Poster presented at North American Refugee Health Conference, Niagara Falls, NY, June 2016

     “Exercising to Fix a Broken Heart: Cardiac Rehabilitation for Patients with Takotsubo Cardiomyopathy”

    Carolyn Wu, Harsha V. Ganga, , John McKeon, , J. Dawn Abbott, , Wen-Chih H. Wu,

    Poster presented at American Society for Preventive Cardiology’s 2016 Congress on Atherosclerotic Cardiovascular Disease Prevention, September 2016